Recombinant Human UBE2M/UBC12 Protein

    • Recombinant Human UBE2M / UBC12 Protein-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human UBE2M / UBC12 Protein-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human UBE2M / UBC12 Protein-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033478

      Synonyms:NEDD8-conjugating enzyme Ubc12; NEDD8 carrier protein; NEDD8 protein ligase; Ubiquitin-conjugating enzyme E2 M; UBC12; UBE2M;

      Size:
      • 10μg
      • 50μg
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      Price: $186

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      Overview

      Synonyms NEDD8-conjugating enzyme Ubc12; NEDD8 carrier protein; NEDD8 protein ligase; Ubiquitin-conjugating enzyme E2 M; UBC12; UBE2M;
      Species Human
      Expression_host E.coli
      Sequence Met1-Lys183
      Accession P61081
      Mol_Mass 20.9 kDa
      AP_Mol_Mass 25 kDa

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as a 0.2 μm filtered solution of 50mM HEPES,pH 7.5,2mM DTT,150mM NaCl,10% Glycerol.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      UBE2M is a member of the E2 ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. UBE2M accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. It involved in cell proliferation and is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.

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