Synonyms	Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1;UCH-L1;Neuron Cytoplasmic Protein 9.5;PGP 9.5;PGP9.5;Ubiquitin Thioesterase L1;UCHL1;HEL-117;NDGOA;PARK5;Uch-L1
Species	Human
Expression_host	E.coli
Sequence	Met 1-Ala223
Accession	P09936
Mol_Mass	25.9 kDa
AP_Mol_Mass	26 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 250mM NaCl, 1mM DTT, 10% Glycerol, pH 7.5.
Reconstitution	Not Applicable

Background

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 (UCHL1) belongs to the Peptidase C12 family. UCHL1 is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. UCHL1 is a component of the ubiquitin system, which has a fundamental role in regulating various biological activities. UCHL1 is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity.

Citations

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