Recombinant INSL3 Monoclonal Antibody (AN301891L)
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For research use only.
| Verified Samples | Verified Samples in IHC: Human testis, Human liver(Negative tissue), Human colon(Negative tissue) |
| Dilution | IHC 1:200-1:1000 |
| Isotype | IgG, κ |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant human INSL3 fragment |
| Abbre | INSL3 |
| Synonyms | Insulin-like, Insl, Insulin-like 3, Leydig insulin-like peptide, ley-I-L, Relaxin-like factor, RLF, RLNL, INSL3 |
| Swissprot | |
| Cellular Localization | Secreted |
| Concentration | 1 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A purified |
| Research Areas | Signal Transduction |
| Clone | A607 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | Insulin-like 3 (INSL3), a Leydig cell-specific hormone, is essential for testis descent during foetal life and bone metabolism in adults. Insl3-deficient mice exhibit bilateral undescended testes located high in the abdominal cavity. INSL3 is presumed also to conform to a heterodimeric A-B structure of approximately 6 kDa once released from the producing cells. It is possible that both the mature form of INSL3 (6.6 kDa) and the pro-form(s) of INSL3 (12-14 kDa) are secreted from mammalian Leydig cells. |
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