Recombinant MCM2 Monoclonal Antibody (AN301274L)
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For research use only.
| Verified Samples | Verified Samples in IHC: Human colon |
| Dilution | IHC 1:200-1:1000, WB 1:2000-1:10000, IF 1:200-1:1000, ELISA 1:5000-1:20000, |
| Isotype | IgG,κ |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant Human MCM2 protein |
| Abbre | MCM2 |
| Synonyms | MCM, cdc, D3S, Ccnl, CDCL, DFNA, KIAA, MCM2, BM28, CCNL1, CDCL1, D3S3194, DFNA70, MITOTIN, cdc19, KIAA0030, CCNL 1, CDC like 1, CDCL 1, Cell devision cycle like 1, Cyclin like 1, DNA replication licensing factor MCM2, MCM 2, MCM2 minichromosome maintenance deficient 2, MCM2 minichromosome maintenance deficient 2 mitotin, MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae), MGC10606, Minichromosome maintenance complex component 2, Minichromosome maintenance deficient 2 (mitotin), Minichromosome maintenance deficient 2 mitotin, Minichromosome maintenance protein 2, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28, OTTHUMP00000216047, OTTHUMP00000216050, MCM2 |
| Swissprot | |
| Cellular Localization | Nucleus, Chromosome, Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. |
| Concentration | 0.2 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A |
| Research Areas | Epigenetics and Nuclear Signaling |
| Clone | B1037 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. |
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