Recombinant Mouse 14-3-3 sigma/YWHAS Protein

    • Recombinant Mouse 14-3-3 sigma / Stratifin / YWHAS Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse 14-3-3 sigma / Stratifin / YWHAS Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse 14-3-3 sigma / Stratifin / YWHAS Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040602

      Synonyms:Er;Mme1;Ywhas

      Size:
      • 50 μg
      • 100 μg
      Qty:
      - +
      Price: $454

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms Er;Mme1;Ywhas
      Species Mouse
      Expression_host E.coli
      Sequence Met 1-Ser 248
      Accession NP_061224.2
      Mol_Mass 27.7 kDa
      AP_Mol_Mass 32 kDa

      Properties

      Purity > 95 % as determined by SDS-PAGE
      Endotoxin Please contact us for more information.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile 50mM Tris, 150mM NaCl, pH 8.0
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathway. More than 100 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2, and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally, YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression.

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