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Recombinant Mouse ANPEP / APN / CD13 Protein (His tag)

Uniprot : NP_032512.2
  • Cat.No.:PKSM040927

  • Expression host: HEK293 Cells

To Purchase PKSM040927

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  • 10µg
  • 20µg
Price: $454
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Description

Synonyms AP-M;AP-N;Apn;Cd13;P150
Species Mouse
Expression_host HEK293 Cells
Sequence Lys 66-Ser 966
Accession NP_032512.2
Mol_Mass 104 kDa
AP_Mol_Mass 120-130 kDa
Tag C-His
Bio_Activity Measured by its ability to cleave the fluorogenic peptide substrate, Ala-7-amido-4-methylcoumarin (Ala-AMC). The specific activity is >800 pmoles/min/µg.

Properties

Purity > 97 % as determined by SDS-PAGE
Endotoxin level < 1.0 EU per µg of the protein as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Reconstitution Please refer to the printed manual for detailed information.

Background

Aminopeptidase N (ANPEP or APN), also known as CD13, is a cell-surface metalloprotease located in the small-intestinal and renal microvillar membrane, as well as other plasma membranes. It belongs to the peptidase M1 family. CD13 plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases and is involved in the metabolism of regulatory peptides by diverse cell types. CD13/APN is a potent regulator of angiogenesis which is essential for tumor invasion and metastasis, and its transcription in activated endothelial cells is induced by angiogenic growth factors via the RAS/MAPK pathway. In addition, this enzyme has been shown to participate in antigen processing and presentation, and accordingly, defects in this gene appear to be a cause of various types of leukemia or lymphoma and carcinomas.

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