Recombinant Mouse c-kit/CD117 Protein (His Tag)(Active)

    • Recombinant Mouse c-kit / CD117 Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse c-kit / CD117 Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse c-kit / CD117 Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040632

      Synonyms:Bs;c-KIT;CD117;Fdc;Gsfsco1;Gsfsco5;Gsfsow3;SCO1;SCO5;SOW3;Ssm;Tr-kit;W

      Size:
      • 50 μg
      • 100 μg
      Qty:
      - +
      Price: $454

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms Bs;c-KIT;CD117;Fdc;Gsfsco1;Gsfsco5;Gsfsow3;SCO1;SCO5;SOW3;Ssm;Tr-kit;W
      Species Mouse
      Expression_host HEK293 Cells
      Sequence Met 1-Thr 523
      Accession NP_001116205.1
      Application Functional ELISA
      Mol_Mass 57 kDa
      AP_Mol_Mass 70-80 kDa
      Tag C-His
      Bio_Activity Measured by its binding ability in a functional ELISA. Immobilized mouse KIT at 2 µg/ml (100 μl/well) can bind biotinylated mouse KITL with a linear ranger of 1.28-6.4 ng/ml.

      Properties

      Purity > 97 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains.and 1 protein kinase domain. It belongs to the protein kinase superfamily, tyr protein kinase family and CSF-1/PDGF receptor subfamily. C-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. C-Kit has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase. Antibodies to c-Kit are widely used in immunohistochemistry to help distinguish particular types of tumour in histological tissue sections. It is used primarily in the diagnosis of GISTs. In GISTs, c-Kit staining is typically cytoplasmic, with stronger accentuation along the cell membranes. C-Kit antibodies can also be used in the diagnosis of mast cell tumours and in distinguishing seminomas from embryonal carcinomas. Mutations in c-Kit gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Defects in KIT are a cause of acute myelogenous leukemia (AML). AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. Note=Somatic mutations that lead to constitutive activation of KIT are detected in AML patients.

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