Synonyms	Basigin; Basic immunoglobulin superfamily; HT7 antigen; Membrane glycoprotein gp42; CD147; Bsg;AI115436;AI325119;EMMPRIN;HT-7
Species	Mouse
Expression_host	Human Cells
Sequence	Ala22-Arg325
Accession	NP_001070652.1
Mol_Mass	34.1 kDa
AP_Mol_Mass	45-60 kDa
Tag	C-6His

Properties

Purity	> 90 % as determined by SDS-PAGE
Endotoxin level	< 1.0 EU per µg as determined by the LAL method.
Storage	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	LyopHilized from a 0.2 μM filtered solution of PBS, pH7.4.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Basigin/CD147 is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression.

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