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Recombinant Mouse CD40/TNFRSF5 Protein (Fc Tag)

  • Cat.No.:PKSM041225

  • Expression host: Human Cells

To Purchase PKSM041225

Size:
  • 10μg
  • 50μg
Price: $92
Qty:

Description

Synonyms Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CD40; TNFRSF5;I326936;HIGM1; IGM; IMD3; p50; T-BAM; Tnfrsf5; TRAP
Species Mouse
Expression_host Human Cells
Sequence Leu20-Arg193
Accession P27512
Mol_Mass 46.5 kDa
AP_Mol_Mass 50-58 kDa
Tag C-Fc

Properties

Purity > 95 % as determined by SDS-PAGE
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution Please refer to it for detailed information.

Background

CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins (adaptor proteins) have been identified to serves as mediators of the signal transduction. CD40 plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.

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