Recombinant Mouse CTLA4/CD152 Protein (His Tag)(Active)

    • Recombinant Mouse CTLA4 / CD152 Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse CTLA4 / CD152 Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse CTLA4 / CD152 Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040643

      Synonyms:Cd152;Ctla-4;Ly-56

      Size:
      • 100 μg
      • 200 μg
      Qty:
      - +
      Price: $338

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms Cd152;Ctla-4;Ly-56
      Species Mouse
      Expression_host HEK293 Cells
      Sequence Met 1-Phe 162
      Accession NP_033973.2
      Application Functional ELISA
      Mol_Mass 15.3 kDa
      AP_Mol_Mass 25-30 kDa
      Tag C-His
      Bio_Activity 1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant mouse CTLA4-His at 10 µg/ml (100 μl/well) can mouse CD80-Fc with a linear range of 0.78-62.5 ng/ml.3. Immobilized recombinant mouse CTLA4-His at 10 µg/ml (100 μl/well) can

      Properties

      Purity > 98 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).

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      MSDS for ELISA ISO 9001

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