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Recombinant Mouse DR6/TNFRSF21 Protein (His Tag)

  • Cat.No.:PKSM041229

  • Expression host: Human Cells

To Purchase PKSM041229

Size:
  • 10μg
  • 50μg
Price: $117
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Description

Synonyms Tumor necrosis factor receptor superfamily member 21;Death receptor 6;Tnfrsf21;CD358;BM-018;DR6
Species Mouse
Expression_host Human Cells
Sequence Gln42-His349
Accession NP_055267.1
Mol_Mass 64.7 kDa
Tag C-6His

Properties

Purity > 95 % as determined by SDS-PAGE
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution Please refer to it for detailed information.

Background

Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

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