Synonyms	Neurotrophic tyrosine kinase receptor-related 1;receptor tyrosine kinase-like orphan receptor 1;ROR1;tyrosine-protein kinase transmembrane receptor ROR1;Epithelial cell adhesion molecule;Tumor-associated calcium signal transducer 1;TROP1;CD326;EGP;EGP-2;Egp314;Ep-CAM;EpCAM1;GA733-2;gp40;Ly74;Tacsd1;Tacstd1
Species	Mouse
Expression_host	HEK293 Cells
Sequence	Gln24-Thr266
Accession	Q99JW5
Application	Functional ELISA
Mol_Mass	54.8 kDa
AP_Mol_Mass	60-80 kDa
Tag	C-Fc

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Epithelial Cellular Adhesion Molecule (Ep-CAM), also known as EGP314, mEGP314, Protein 289A, Tumor-associated calcium signal transducer 1, CD326, belongs to the EPCAM family. Its’ monomer subunit structure interacts with phosphorylated CLDN7. Ep-CAM may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. It plays a role in embryonic stem cells proliferation and differentiation. It also up-regulates the expression of FABP5, MYC and cyclins A and E. The post-translational modification glycosylation at Asn-198 is crucial for protein stability.

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