Recombinant Mouse EphA4/HEK8 Protein (Fc Tag)(Active)

    • Recombinant Mouse EphA4 / HEK8 Protein (Fc tag)(Fc tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse EphA4 / HEK8 Protein (Fc tag)(Fc tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse EphA4 / HEK8 Protein (Fc tag)(Fc tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040604

      Synonyms:2900005C20Rik;AI385584;Cek8;Hek8;rb;Sek;Sek1;Tyro1

      Size:
      • 100 μg
      • 200 μg
      Qty:
      - +
      Price: $206

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms 2900005C20Rik;AI385584;Cek8;Hek8;rb;Sek;Sek1;Tyro1
      Species Mouse
      Expression_host HEK293 Cells
      Sequence Met 1-Thr 547
      Accession NP_031962.2
      Application Functional ELISA
      Mol_Mass 85.3 kDa
      AP_Mol_Mass 110 kDa
      Tag C-Fc
      Bio_Activity Measured by its binding ability in a functional ELISA. Immobilized mouse EPHA5 at 2 µg/ml (100 μl/well) can bind mouse EFNA4-Fc with a linear ranger of 1.28-32 ng/ml.

      Properties

      Purity > 95 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      EPH receptor A4 (ephrin type-A receptor 4), also known as EphA4, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. EphA4 is enriched on dendritic spines of pyramidal neurons in the adult mouse hippocampus, and ephrin-A3 is localized on astrocytic processes that envelop spines. Eph receptor−mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). The extracellular domain of an EphA4 interacts with ephrin ligands, which may be tethered to neighbouring cells. Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer.

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