Recombinant Mouse Fetuin-A/AHSG Protein (His Tag)(Active)

    • Recombinant Mouse Fetuin-A / AHSG Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse Fetuin-A / AHSG Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse Fetuin-A / AHSG Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040869

      Synonyms:Alpha-2-HS-glycoprotein; Ahsg; Countertrypin; Fetuin-A; Fetua

      Size:
      • 50 μg
      • 100 μg
      Qty:
      - +
      Price: $454

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms Alpha-2-HS-glycoprotein; Ahsg; Countertrypin; Fetuin-A; Fetua
      Species Mouse
      Expression_host HEK293 Cells
      Sequence Met1-Ile 345
      Accession NP_032037.2
      Application Functional ELISA
      Mol_Mass 36.7 kDa
      AP_Mol_Mass 50 kDa
      Tag C-His
      Bio_Activity 1. Measured by its binding ability in a functional ELISA. Immobilized human FCN1 at 10 µg/mL can bind biotinylated recombinant mouse Fetuin-A with a linear range of 16-2000 ng/ml.2. Measured by its ability to inhibit trypsin cleavage of a fluorogenic pept

      Properties

      Purity > 95 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile 25mM Tris, 0.15mM NaCl, pH 7.5
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Fetuin-A, also known as Alpha-2-HS-Glycoprotein (AHSG), belongs to the Fetuin family, is a plasma binding protein, and is more abundant in fetal than adult blood. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Fetuins are carrier proteins like albumin. Fetuin-A forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus Fetuin-A is a potent inhibitor of pathological calcification. The circulating levels of fetuin-A, a well-described inhibitor of calcification, regulate the cell-dependent process of osteogenesis. The low circulating fetuin-A levels are associated with a greater prevalence and/or severity of Vascular calcification (VC) and increased risk for all-cause and cardiovascular mortality. However, high circulating fetuin-A levels appear to induce insulin resistance and, in non-dialyzed subjects with diabetic nephropathy, are directly related to VC burden. The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in cross-sectional studies demonstrating a significant correlation with all-cause and cardiovascular mortality. Additionally, Human fetuin-A is a negative acute phase protein involved in inflammatory diseases, thus being a potential physiological regulator of meprin activity. Fetuin-A is a broad-range protease inhibitor. Fetuin-A and cystatin C as endogenous proteolytic regulators of meprin activity broadens our understanding of the proteolytic network in plasma.

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