Recombinant Mouse FLRG/Fstl3 Protein (His Tag)(Active)

    • Recombinant Mouse FLRG / Fstl3 Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse FLRG / Fstl3 Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse FLRG / Fstl3 Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040903

      Synonyms:E030038F23Rik;Flrg

      Size:
      • 20 μg
      • 50 μg
      Qty:
      - +
      Price: $365

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms E030038F23Rik;Flrg
      Species Mouse
      Expression_host HEK293 Cells
      Sequence Met 1-Val 256
      Accession NP_113557.1
      Application Functional ELISA
      Mol_Mass 26 kDa
      AP_Mol_Mass 35-40 kDa
      Tag C-His
      Bio_Activity 1. Measured by its binding ability in a functional ELISA. Immobilized mouse FLRG-His at 10 µg/ml (100 μl/well) can bind biotinylated human INHBA-His with a linear range of 6.25-50 ng/ml.2. Measured by its binding ability in a functional ELISA. Immobilized

      Properties

      Purity > 85 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Follistatin-like 3 (FLRG/Fstl3) is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. FLRG/Fstl3 is a recently described member of the FST family having an overall structure and activity profile similar to that of FST, including binding and neutralization of activin. FLRG/Fstl3 is expressed in a wide range of adult tissues, not detected in hematopoietic cells except in patients with a B cell chronic leukemia and a translocation. Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 of FLRG/Fstl3 or the nuclear form of FLRG/Fstl3 is probably involved in transcriptional regulation via interaction with MLLT10. Modulation of activin and other TGFβ superfamily signaling is the primary mechanism of action for both follistatin (FS) and FS-like 3 (FSTL-3). FLRG/Fstl3 is likely to be a local regulator of activin action in gonadal development and gametogenesis and, further, that activin appears to have important actions in gonadal development and function that are critical for normal reproduction.

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      MSDS for ELISA ISO 9001

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