Recombinant Mouse IgG1-Fc Protein (102 Cys/Ser)

    • Recombinant Mouse IgG1-Fc Protein (102 Cys/Ser)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse IgG1-Fc Protein (102 Cys/Ser)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse IgG1-Fc Protein (102 Cys/Ser)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040928

      Synonyms:IgG1;Igh-4;VH7183

      Size:
      • 100 μg
      • 200 μg
      Qty:
      - +
      Price: $206

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms IgG1;Igh-4;VH7183
      Species Mouse
      Expression_host HEK293 Cells
      Sequence Val 98-Lys 324
      Accession P01868-1
      Mol_Mass 25.8 kDa
      AP_Mol_Mass 32 kDa

      Properties

      Purity > 97 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile 100mM NaAc, 10mM NaCl, 200mM Tris, pH 7.5
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells, and constitutes 75% of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetramer contains two heavy chains (50 kDa ) and two light chains (25 kDa) linked by disulfide bonds, that is the two identical halves form the Y-like shape. IgG is digested by pepsin proteolysis into Fab fragment (antigen-binding fragment) and Fc fragment ("crystallizable" fragment). IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR ) on phagocytic cells with high affinity. Fc fragment is demonstrated to mediate phagocytosis, trigger inflammation, and target Ig to particular tissues. Protein G or Protein A on the surface of certain Staphylococcal and Streptococcal strains specifically binds with the Fc region of IgGs, and has numerous applications in biotechnology as a reagent for affinity purification. Recombinant IgG Fc Region is suggested to represent a potential anti-inflammatory drug for treatment of human autoimmune diseases.

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