Recombinant Mouse IL-21R Protein (His Tag)

    • Recombinant Mouse Interleukin-21 Receptor / IL-21R Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Mouse Interleukin-21 Receptor / IL-21R Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Mouse Interleukin-21 Receptor / IL-21R Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSM041316

      Synonyms:Interleukin-21 receptor; IL-21 receptor; IL-21R; Il21r; Nilr

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $62

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Interleukin-21 receptor; IL-21 receptor; IL-21R; Il21r; Nilr
      Species Mouse
      Expression_host Human Cells
      Sequence Cys20-Pro236
      Accession Q9JHX3
      Mol_Mass 25.7 kDa
      AP_Mol_Mass 34-38 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. IL-21R is expressed mainly on B cells, NK cells, and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells, and keratinocytes. Both IL-21 and IL-4 are necessary for efficient B cell IgG1 production and normal germinal center architecture. B cell IL-21 R engagement induces Blimp-1(which mediates plasma cell differentiation), and is important for memory responses. IL-21R engagement on mouse NK cells enhances their cytotoxic activity and IFN-γ production. IL-21R engagement on CD8+ T cells aids control of viral infection and tumor growth? IL-21R is also necessary for sufficient numbers of regulatory T cells to combat chronic inflammation. IL-21R expression is often up-regulated in allergic skin inflammation, systemic lupus erythematosus and diffuse large B cell lymphoma (DLBCL).

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