Synonyms	Interleukin-12 subunit beta;IL-12 subunit p40;IL-12B;Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit (CLMF p40);NK cell Stimulating Factor Chain 2
Species	Mouse
Expression_host	E.coli
Sequence	Gln 19-Pro 144
Accession	P15247
Mol_Mass	15.0 kDa
AP_Mol_Mass	12 kDa
Tag	N-His
Bio_Activity	Measure by its ability to induce proliferation in MO7e cells.The ED₅₀ for this effect is <0.2 ng/mL.The specific activity of recombinant mouse IL-9 is > 5 x 10⁶ IU/mg.

Properties

Purity	> 98 % as determined by reducing SDS-PAGE.
Endotoxin level	< 0.1 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Interleukin-9 (IL-9) is a secreted protein that belongs to the IL-7/IL-9 family.Mature mouse IL-9 shares 57% and 74% amino acid sequence identity with human and rat IL-9, respectively. IL-9 supports IL-2 independent and IL-4 independent growth of helper T-cells. IL-9 stimulates cell proliferation and prevents apoptosis. It functions through the IL-9 receptor (IL-9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. IL-9 has been identified as a candidate gene for asthma. IL-9 is a determining factor in the pathogenesis of bronchial hyperresponsiveness.

Citations

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