Recombinant Mouse Interleukin-13/IL-13 Protein (Active)

    • Recombinant Mouse IL-13 Protein (Pro22-Phe131)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Mouse IL-13 Protein (Pro22-Phe131)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Mouse IL-13 Protein (Pro22-Phe131)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSM041322

      Synonyms:Interleukin-13; IL-13; T-Cell Activation Protein P600; Il13; Il-13

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $178

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      Overview

      Synonyms Interleukin-13; IL-13; T-Cell Activation Protein P600; Il13; Il-13
      Species Mouse
      Expression_host E.coli
      Sequence Pro22-Phe131
      Accession P20109
      Application Cell Culture
      Mol_Mass 12.2 kDa
      AP_Mol_Mass 12 kDa
      Bio_Activity Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is 0.1-1 ng/ml.

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13Rα1 with low affinity and triggers association of IL4Rα, generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13Rα2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.

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