Recombinant Mouse LAMP1/CD107a Protein (His Tag)

    • Recombinant Mouse LAMP1 / CD107a Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Mouse LAMP1 / CD107a Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Mouse LAMP1 / CD107a Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSM041307

      Synonyms:Lysosome-associated membrane glycoprotein 1; LAMP-1; Lysosome-associated membrane protein 1; 120 kDa lysosomal membrane glycoprotein; CD107 antigen-like family member A; LGP-120; Lysosomal membrane glycoprotein A; LGP-A; P2B; CD107a

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $111

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      Overview

      Synonyms Lysosome-associated membrane glycoprotein 1; LAMP-1; Lysosome-associated membrane protein 1; 120 kDa lysosomal membrane glycoprotein; CD107 antigen-like family member A; LGP-120; Lysosomal membrane glycoprotein A; LGP-A; P2B; CD107a
      Species Mouse
      Expression_host Human Cells
      Sequence Leu25-Asn370
      Accession P11438
      Mol_Mass 38.6 kDa
      AP_Mol_Mass 55-94 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Lysosomal associated membrane protein 1 (LAMP1) is an approximately 120 kDa transmembrane glycoprotein that is a major protein component of lysosomal membranes. Mature mouse LAMP1 consists of a 346 amino acid (aa) intralumenal domain (ECD), a 24 aa transmembrane segment, and a 12 aa cytoplasmic tail. Its lumenal domain is organized into two heavily N-glycosylated regions separated by a Ser/Pro-rich linker that carries a minor amount of O-linked glycosylation. Within the lumenal domain, mouse LAMP1 shares approximately 64% and 82% aa sequence identity with human and rat LAMP1, respectively. The sorting of LAMP1 to lysosomes relies on a tyrosine motif in the cytoplasmic tail. In cytotoxic T cells and mast cells, LAMP1 is expressed in the membranes of intracellular granules that contain effector molecules such as perforin, granzymes, eicosanoids, and histamine. A glycoform of LAMP1 known as M150 is expressed on the surface of activated macrophages where it promotes T cell co-stimulation and a Th1 biased immune response. Exposure of epithelial cells to pathogenic Neisseria bacteria induces the redistribution of LAMP1 to the cell surface where it can be cleaved by the Neisseria IgA1 protease.

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      MSDS for ELISA ISO 9001

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