Synonyms	TNFSF4;Ath;Ath-;Ath-1;Ath1;CD134;CD134L;OX-40L;OX4;TXGP1;Tnlg2b;Txgp;Txgp1l;gp3;gp34
Species	Mouse
Expression_host	E.coli
Sequence	Lys32-Pro187
Accession	P07141
Mol_Mass	19.0 kDa
AP_Mol_Mass	17-25 kDa
Tag	C-His
Bio_Activity	Measure by its ability to induce proliferation in NFS-60 cells.The ED₅₀ for this effect is <2 ng/mL.The specific activity of recombinant mouse M-CSF is approximately >5 x 10⁵ IU/mg.

Properties

Purity	> 98 % as determined by reducing SDS-PAGE.
Endotoxin level	< 0.1 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from sterile PBS,pH 8.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Macrophage colony-stimulating factor 1（M-csf）is a single-pass type I membrane protein . It is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity. The role of M-CSF is not only restricted to the monocyte/macrophage cell lineage. By interacting with its membrane receptor, M-CSF also modulates the proliferation of earlier hematopoietic progenitors and influence numerous physiological processes involved in immunology, metabolism, fertility and pregnancy.

Citations

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