Recombinant Mouse Motch A/NOTCH1 Protein (His Tag)

    • Recombinant Mouse Notch 1 / Motch A Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Mouse Notch 1 / Motch A Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Mouse Notch 1 / Motch A Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSM041299

      Synonyms:Neurogenic locus notch homolog protein 1; Notch 1; Motch A; Mt14;lin-12;Mis6;N1;Tan1

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $117

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      Overview

      Synonyms Neurogenic locus notch homolog protein 1; Notch 1; Motch A; Mt14;lin-12;Mis6;N1;Tan1
      Species Mouse
      Expression_host Human Cells
      Sequence Ala18-Gln526
      Accession Q01705
      Mol_Mass 54.4 kDa
      AP_Mol_Mass 70 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Mouse Notch1 is a 300 kDa type I transmembrane glycoprotein and it functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Mouse Notch1 is synthesized as a 2531 amino acid (aa) precursor that contains an 18 aa signal sequence, a 1707 aa extracellular domain (ECD) with 36 EGFlike repeats and three Lin12/notch repeats, a 21 aa transmembrane segment and a 785 aa cytoplasmic domain that contains six ankyrin repeats, a glutamine-rich domain and a PEST sequence. Notch1 may play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation and may be involved in mesoderm development, somite formation and neurogenesis.

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