Click here to view cell apoptosis assay products
×

Recombinant Mouse OX40/TNFRSF4 Protein (His Tag)(Active)

  • Cat.No.:PKSM041200

  • Expression host: Human Cells

To Purchase PKSM041200

Size:
  • 10μg
  • 50μg
Price: $117
Qty:

Description

Synonyms Tumor necrosis factor receptor superfamily member 4;Tnfrsf4;OX40;CD134;Txgp1
Species Mouse
Expression_host Human Cells
Sequence Val20-Pro211
Accession P47741
Application Functional ELISA
Mol_Mass 22.1 kDa
AP_Mol_Mass 40 kDa
Tag C-6His
Bio_Activity Immobilized Mouse OX40L-His(Cat: PKSM041119) at 0.8μg/ml(100 μl/well) can bind Biotinylated Mouse OX40-His. The ED50 of Mouse OX40-His is 23.17 ug/ml .

Properties

Purity > 95 % as determined by SDS-PAGE
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution Please refer to it for detailed information.

Background

OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.

Related Products

Citations

From now on, if you have published a paper by using any of our products since 1/1/2019, fill out the “Elabscience Publication Reward Application Form”carefully and send it to orders@elabscience.com, we will get back to you with the reward after we confirm it ASAP!

View more details about our Publication Reward >>

Reviews/Q&A

  • Show all
  • Reviews
  • Q&A
... Show All Show Less

People Also Bought

Apply for
*Product Name:
*Catalog Number:
*Name:
*Email:
*Message:
*Country:
*When will you use it?

*Captcha: