Recombinant Mouse PPM1A Protein (His Tag)

    • Recombinant Mouse PPM1A / PP2CA / PP2C-alpha Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse PPM1A / PP2CA / PP2C-alpha Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse PPM1A / PP2CA / PP2C-alpha Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040761

      Synonyms:2310003C21Rik;2900017D14Rik;AI427932;AU017636;MMPa-2;MPPa-1

      Size:
      • 50 μg
      • 100 μg
      Qty:
      - +
      Price: $454

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms 2310003C21Rik;2900017D14Rik;AI427932;AU017636;MMPa-2;MPPa-1
      Species Mouse
      Expression_host E.coli
      Sequence Met 1-Trp 382
      Accession NP_032936.1
      Mol_Mass 43.3 kDa
      AP_Mol_Mass 43.3 kDa
      Tag C-His

      Properties

      Purity > 98 % as determined by SDS-PAGE
      Endotoxin Please contact us for more information.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile 10mM HEPES, 500 NaCl, pH 7.5
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Protein phosphatase 1A (PPM1A / PP2CA) is an enzyme belonging to the PP2C family of Ser / Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and MAP kinase kinases. It has also been demonstrated to inhibit the activation of p38 and JNK kinase cascades. PPM1A dephosphorylates and promotes nuclear export of TGFβ-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFβ-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFβ signaling in mammalian cells. It has been demonstrated that PPM1A / PP2CA, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFβ signaling. Overexpression of PPM1A is reported to activate the expression of the tumor suppressor gene TP53 / p53, which leads to cell apoptosis.

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