Recombinant Mouse Prostasin/PRSS8 Protein (aa 30-289, His Tag)

    • Recombinant Mouse Prostasin / PRSS8 Protein (aa 30-289, His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse Prostasin / PRSS8 Protein (aa 30-289, His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse Prostasin / PRSS8 Protein (aa 30-289, His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040855

      Synonyms:2410039E18Rik;AI313909;C79772;CAP1;fr;mCAP1

      Size:
      • 10 μg
      • 20 μg
      Qty:
      - +
      Price: $454

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms 2410039E18Rik;AI313909;C79772;CAP1;fr;mCAP1
      Species Mouse
      Expression_host Baculovirus-Insect Cells
      Sequence Ala 30-Gln 289
      Accession EDL17608.1 
      Mol_Mass 29.3 kDa
      AP_Mol_Mass 35 kDa
      Tag C-His

      Properties

      Purity > 97 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from human seminal fluid and is highly expressed in prostate, lung, kidney, salivary gland and pancreas. Prostasin is expressed as a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein in prostate epithelial cells, and also exists as a secreted proteolytic enzyme possibly via tryptic cleavage of its COOH-terminal hydrophobic domain. Prostasin is found to activate the epithelial sodium channel (ENaC) which is tightly regulated and is critical for maintaining salt and fluid balance in the lung and kidney in both normal and pathological conditions. Accordingly, prostasin has been proposed as a target for therapeutic inhibition in cystic fibrosis. In addition, prostasin inhibits prostate and breast cancer cell invasion in vitro, suggesting a functional role as a suppressor of tumor invasion, as well as a regulator of gene expression during inflammation.

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