Synonyms	Protein S100-A8;Calgranulin-A;Chemotactic cytokine CP-10;Leukocyte L1 complex light chain;Migration inhibitory factor-related protein 8;MRP-8;Pro-inflammatory S100 cytokine;S100 calcium-binding protein A8;S100a8;Caga; Mrp8;60B8Ag;AI323541;B8Ag;Caga;CFAg;CP-10;p8
Species	Mouse
Expression_host	E.coli
Sequence	Met1-Glu89
Accession	P27005
Mol_Mass	11.3 kDa
AP_Mol_Mass	13 kDa
Tag	C-6His

Properties

Purity	> 95 % as determined by SDS-PAGE
Endotoxin level	< 1.0 EU per µg as determined by the LAL method.
Storage	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mMTris，pH8.0.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Protein S100-A8(Mrp8) contains 2 EF-hand domains and belongs to the S-100 family. Mrp8 binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. It may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.

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