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Recombinant Mouse Serpin A3N Protein (His Tag)

  • Cat.No.:PKSM041279

  • Expression host: Human Cells

To Purchase PKSM041279

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  • 10μg
  • 50μg
Price: $328
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Description

Synonyms Serine protease inhibitor A3N; Serpin A3N; Serpina3n; Spi2
Species Mouse
Expression_host Human Cells
Sequence Phe21-Lys418
Accession Q91WP6
Mol_Mass 45.6 kDa
AP_Mol_Mass 58 kDa
Tag C-His

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0 .
Reconstitution Please refer to the printed manual for detailed information.

Background

Serine protease inhibitor A3N(Serpin A3N) is a serine protease inhibitor that is structurally related to α1 antichymotrypsin encoded by the SERPINA3 gene. Serpin A3N is highly expressed in brain, testis, lung, thymus, and spleen. It is expressed with low levels in bone marrow, kidney and skeletal muscle. Serpin A3N secreted by Sertoli cells may regulate the activity of locally produced Granzyme B. Granzyme B inhibition by Serpin A3N may therefore regulate Granzyme Bmediated killing by cytotoxic lymphocytes, providing a means to disable cellmediated immune responses.

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