Synonyms	Alpha-1-antitrypsin 1-3;Alpha-1 protease inhibitor 3;Alpha-1 protease inhibitor 6;Alpha-1-antitrypsin 1-6;Serine protease inhibitor 1-3;Serine protease inhibitor 1-6;Serine protease inhibitor A1c;Serpin A1c;Serpina1c;Dom3;Dom6;Spi1-3;Spi1-6
Species	Mouse
Expression_host	HEK293 Cells
Sequence	Glu25-Lys413
Accession	AAH11040.1
Mol_Mass	44.3 kDa
AP_Mol_Mass	50-60 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Reconstitution	Not Applicable

Background

Alpha-1-antitrypsin 1-3(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase,plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein have been found for this gene.

Citations

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