Synonyms	Gal-beta-1;3-GalNAc alpha-2;6-sialyltransferase;GalNAc alpha-2;6-sialyltransferase II;ST6GalNAc II;Sialyltransferase 7B;SIAT7-B;II;Siat7;Siat7b;ST6GalNAc
Species	Mouse
Expression_host	HEK293 Cells
Sequence	Ser28-Arg373
Accession	P70277
Mol_Mass	40.4 kDa
AP_Mol_Mass	45 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 50mMTris,150mMNaCl,pH7.5.
Reconstitution	Not Applicable

Background

Alpha-N-acetylgalactosaminide alpha -2,6-sialyltransferase 2, is a type?II membrane protein localized in the Golgi network and catalyzes 2,6-sialylation of the Tn antigen. Sialyl-Tn antigen is highly expressed in several human carcinomas and is associated with carcinoma aggressiveness and poor prognosis.?it has been reported that disregulation of this gene is involved in the pathogenesis of IgA nephropathy, a common kidney disease that occurs when antibody IgA accumulates in kidneys (4). The enzyme may also be used to synthesize a cancer vaccine.

Citations

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