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Recombinant Mouse TNFSF9 Protein (His Tag) (Active)

  • Cat.No.:PKSM041162

  • Expression host: Human Cells

To Purchase PKSM041162

Size:
  • 10μg
  • 50μg
Price: $129
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Description

Synonyms Tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL; Tnfsf9; Cd137l; Cd157l; Ly63l
Species Mouse
Expression_host Human Cells
Sequence Arg104-Glu309
Accession P41274
Application Functional ELISA
Mol_Mass 25.6 kDa
AP_Mol_Mass 35-40 kDa
Tag N-10His
Bio_Activity Immobilized Mouse 4-1BBL-His at 2μg/ml(100 μl/well) can bind Human 4-1BB-Fc(Cat: PKSH032026).

Properties

Purity > 95 % as determined by SDS-PAGE
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.

Background

Tumor necrosis factor ligand superfamily member 9, also known as 4-1BBL, is a member of the the tumor necrosis factor family. Mouse 4-1BBL cDNA encodes a 309 amino acid residues (aa) protein with an 82 aa N-terminal cytoplasmic domain, a 21 aa transmembrane domain and a 206 aa C-terminal extracellular domain. The extracellular domain of 4-1BBL has a tertiary structure similar to that of other TNFSF members, but shares only low aa sequence homology (14-16%). 4-1BBL is predominantly expressed on activated antigen presenting cells (APCs) such as B cells, macrophages and dendritic cells (DCs). It is also expressed on most T and B lymphoma cell lines. TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells, and is thought to be involved in T cell-tumor cell interaction.

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