Recombinant Mouse TRAIL R2/TNFRSF10B Protein (Fc Tag)(Active)

    • Recombinant Mouse TRAILR2 / TNFRSF10B / CD262 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Mouse TRAILR2 / TNFRSF10B / CD262 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Mouse TRAILR2 / TNFRSF10B / CD262 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSM041271

      Synonyms:Tumor Necrosis Factor Receptor Superfamily Member 10B; Death Receptor 5; TNF-Related Apoptosis-Inducing Ligand Receptor 2; TRAIL Receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $117

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      Overview

      Synonyms Tumor Necrosis Factor Receptor Superfamily Member 10B; Death Receptor 5; TNF-Related Apoptosis-Inducing Ligand Receptor 2; TRAIL Receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9
      Species Mouse
      Expression_host Human Cells
      Sequence Asn53-Ser177
      Accession Q9QZM4
      Mol_Mass 40.9 kDa
      AP_Mol_Mass 50-75 kDa
      Tag C-Fc
      Bio_Activity Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L‑929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 92.04 ng/ml in the presence of 40 ng/mL of TNFSF10 .

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Mouse tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a member of the TNFR family which contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10B exhibits high structural and functional homology to TRAIL-R1 (DR-4). TNFRSF10B is highly expressed in heart, lung, lymphocytes, spleen and kidney. In addition, it is regulated by the tumor suppressor p53. TNFRSF10B is the receptor for the cytotoxic ligand TNFSF10/TRAIL. It promotes the activation of NF-kappa-B and is essential for ER stress-induced apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis.

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      MSDS for ELISA ISO 9001

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