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Recombinant Mouse XEDAR/EDA2R Protein (His Tag)

Uniprot : Q8BX35
  • Cat.No.:PKSM041221

  • Expression host: Human Cells

To Purchase PKSM041221

  • 10µg
  • 50µg
Price: $92


Synonyms Ectodysplasin A2 receptor; EDA-A2 receptor; EDA-A2R; Tumor necrosis factor receptor superfamily member XEDAR; Tumor necrosis factor receptor superfamily member 27; X-linked ectodysplasin-A2 receptor;EDAA2R; TNFRSF27; XEDAR;EDAR2
Species Mouse
Expression_host Human Cells
Sequence Met1-Thr138
Accession Q8BX35
Mol_Mass 16.4 kDa
AP_Mol_Mass 26 kDa
Tag C-6His


Purity > 95 % as determined by SDS-PAGE
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution Please refer to it for detailed information.


Tumor necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR superfamily. EDA2R consists of extracellular domain (ECD) with 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. EDA2R is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, EDA2R can associate with Fas and induce EDA-A2 dependent apoptosis. Its transcription is directly induced by p53, and it mediated cell death is p53 dependent. it is down-regulated in breast, colon, and lung cancers, particularly in cases with p53 mutations. It also plays a role in EDA-A2 induced skeletal muscle degeneration and osteoblast differentiation. Mutations in the EDA gene are associated with the X-linked form of Hypohidrotic Ectodermal Dysplasia (HED), a disease typically characterized by abnormal hair, teeth and sweat glands.

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