Recombinant PAX8 Monoclonal Antibody (AN301620L)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Human thyroid, Mouse thyroid, Rat thyroid Verified Samples in IF: SK-OV-3 |
| Dilution | IHC 1:50-1:100, IF 1:50 |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant human PAX8 fragment |
| Abbre | PAX8 |
| Synonyms | OTTHUMP00000158659, OTTHUMP00000158660, OTTHUMP00000203723, OTTHUMP00000203724, Paired box, Paired box 8, Paired box gene, Paired box gene 8, paired box homeotic gene, paired box homeotic gene 8, Paired box protein Pax 8, Paired box protein Pax-8, Paired domain gene, Paired domain gene 8, PAX, PAX 8, PAX8 |
| Swissprot | |
| Cellular Localization | Nucleus |
| Concentration | 1 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A purified |
| Research Areas | Neuroscience, Epigenetics and Nuclear Signaling |
| Clone | C141243 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | PAX8 is one of nine transcription factors within the PAX gene family. It has been observed to be expressed during embryonic development however expression attenuates after development in all but a few tissues. Research has indicated that over-expression of PAX proteins in general are not an initiating event in tumorgenesis however they may facilitate malignant development. PAX8 is expressed in 80-96% of all High-grade serous carcinomas (HGSC) and is commonly used as a marker for the disease. In addition PAX8 has become a useful biomarker for differentiating between mullerian mucinous and non-mullerian tumors. PAX8 has also been associated with neoplasms in the kidney and thyroid. |
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