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Recombinant Rat GITR/TNFRSF18 Protein (Fc Tag)

  • Cat.No.:PKSR030328

  • Expression host: HEK293 Cells

To Purchase PKSR030328

Size:
  • 50μg
  • 100μg
Price: $454
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Description

Synonyms TNFRSF18
Species Rat
Expression_host HEK293 Cells
Sequence Met1-Lys121
Accession Q5M835
Mol_Mass 37.7 kDa
AP_Mol_Mass 47 kDa
Tag C-Fc

Properties

Purity > 95 % as determined by SDS-PAGE
Endotoxin level < 1.0 EU per µg of the protein as determined by the LAL method
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Reconstitution Please refer to the printed manual for detailed information.

Background

GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.

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