S100A8 Polyclonal Antibody (E-AB-70341)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Mouse Immunized spleen, Rat spleen |
| Dilution | IHC 1:200-1:800 |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein corresponding to Mouse S100A8 |
| Abbre | S100A8 |
| Synonyms | 60B8Ag, AI323541, B8Ag, BEE11, CAGA, CFAG, CGLA, CP-10, Calgranulin-A, Calprotectin, Calprotectin L1L subunit, Chemotactic cytokine CP-10, Cystic fibrosis antigen, L1Ag, Leukocyte L1 complex light chain, M, MA387, MIF, Migration inhibitory factor-related protein 8, included |
| Swissprot | |
| Cellular Localization | Secreted. Cytoplasm. Cytoplasm>cytoskeleton. Cell membrane. Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes. Serum levels are high in patients suffering from chronic inflammation. |
| Concentration | 0.8 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Neuroscience |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. |
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