SARS-COV-2 Spike S2 Polyclonal Antibody(2019-nCoV)

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      Catalog number:E-AB-V1010

      Synonyms:coronavirus s2,coronavirus spike,cov spike,ncov,ncov s2,ncov spike,novel coronavirus s2,novel coronavirus spike,s2

      Size:
      • 50μL
      • 100μL
      Qty:
      - +
      Price: $250

      Host: Rabbit

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms coronavirus s2,coronavirus spike,cov spike,ncov,ncov s2,ncov spike,novel coronavirus s2,novel coronavirus spike,s2
      Source Rabbit
      Reactivity SARS-COV2 Spike S2
      Immunogen Recombinant 2019-nCoV S2 Protein (ECD, His Tag)(PKSR030505)
      Recommended dilution ELISA: 1:5,000-1:10,000
      Concentration 1 mg/mL

      Properties

      Isotype IgG
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer 0.2 μm filtered solution in PBS
      Background Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
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      MSDS for ELISA ISO 9001

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