SEPT4 Polyclonal Antibody

Uniprot : O43236
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-13045

      Synonyms:Apoptosis-related protein in the TGF-beta signaling pathway,ARTS,Bradeion,Bradeion beta,Brain protein H5,CE5B3,CE5B3 beta,Cell division control-related protein 2,Cerebral protein 7,H5,hCDCREL-2,hucep-7,MART,Peanut-like protein 2,PNUTL2,SEP 4,SEP4,Sept4,SEPT4,Septin M,Septin-4

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Apoptosis-related protein in the TGF-beta signaling pathway,ARTS,Bradeion,Bradeion beta,Brain protein H5,CE5B3,CE5B3 beta,Cell division control-related protein 2,Cerebral protein 7,H5,hCDCREL-2,hucep-7,MART,Peanut-like protein 2,PNUTL2,SEP 4,SEP4,Sept4,SEPT4,Septin M,Septin-4
      Swissprot O43236
      Source Rabbit
      Reactivity Human
      Immunogen Synthetic peptide of human SEPT4
      Application IHC(Detection kit: E-IR-R217),ELISA
      Recommended dilution IHC 1:50-1:200
      Concentration 0.4 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm. Cytoplasm>cytoskeleton. In platelets, found in areas surrounding alpha-granules and Mitochondrion. Nucleus. While predominantly localized in the mitochondria under resting conditions, isoform ARTS translocates into the nucleus after TGF-beta treatment and apoptosis induction.
      Tissue specificity Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer.

      Images

      polyclonal antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Human lung cancer tissue using SEPT4 Polyclonal Antibody at dilution 1:50

      polyclonal antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using SEPT4 Polyclonal Antibody at dilution 1:50

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