SGK1 Monoclonal Antibody

Uniprot : O00141
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
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    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience

      Catalog number:E-AB-22207

      Synonyms:OTTHUMP00000017247,Serine/threonine protein kinase SGK,Serine/threonine protein kinase Sgk1,Serine/threonine-protein kinase Sgk1,Serum and glucocorticoid regulated kinase,Serum/glucocorticoid regulated kinase 1,Serum/glucocorticoid regulated kinase,Serum/glucocorticoid-regulated kinase 1,SGK 1,SGK,SGK1,Sgk1 variant i3,SGK1

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Mouse

      Reactivity: H,M,R

      Applications: IHC-p

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms OTTHUMP00000017247,Serine/threonine protein kinase SGK,Serine/threonine protein kinase Sgk1,Serine/threonine-protein kinase Sgk1,Serum and glucocorticoid regulated kinase,Serum/glucocorticoid regulated kinase 1,Serum/glucocorticoid regulated kinase,Serum/glucocorticoid-regulated kinase 1,SGK 1,SGK,SGK1,Sgk1 variant i3,SGK1
      Swissprot O00141
      Source Mouse
      Reactivity Human,Mouse,Rat
      Immunogen Synthetic Peptide of SGK1
      Application IHC-p(Detection kit: E-IR-R217)
      Recommended dilution IHC 1:100-200
      Concentration 1 mg/mL
      Clonality Monoclonal

      Properties

      Cellular localization Cell membrane and Cytoplasm. Nucleus. Endoplasmic reticulum. Nuclear, upon phosphorylation.
      Tissue specificity Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung. Isoform 2 is strongly expressed in brain and pancreas, weaker in heart, placenta, lung, liver and skeletal muscle.
      Clone No. Clone:4D12
      Isotype IgG
      Purification Protein A purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.

      Images

      monoclonal antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Human brain tissue using SGK1 Monoclonal Antibody at dilution of 1:200.

      monoclonal antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Human kidney carcinoma tissue using SGK1 Monoclonal Antibody at dilution of 1:200.

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