SH-PTP1 Polyclonal Antibody
- +1
Price: $ 399
Price: $ 240
Price: $ 143
Price: $ 73
Size:
200μL
120μL
60μL
20μL
Quantity:
- Host: Rabbit
- Reactivity: Human;Mouse;Rat
- Applications: WB;IHC
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Product Details
Verified Samples |
Verified Samples in WB:A375,A431 Verified Samples in IHC:Human colon cancer,Human liver cancer |
Dilution |
WB 1:200-1:1000, IHC 1:50-1:200 Western Blot Operation Guide |
Clonality | Polyclonal |
Immunogen | Recombinant protein of human PTPN6 |
Abbre | PTPN6 |
Synonyms | 70Z-SHP;EC 3.1.3.48;HCP;HCPH;Hematopoietic cell phosphatase;Hematopoietic cell protein tyrosine phosphatase;Hematopoietic cell protein-tyrosine phosphatase;HPTP1C;Protein tyrosine phosphatase 1C;Protein tyrosine phosphatase non receptor type 6;Protein tyrosine phosphatase SHP1;Protein-tyrosine phosphatase 1C;protein-tyrosine phosphatase SHP 1;Protein-tyrosine phosphatase SHP-1;PTN6;PTP 1C;PTP-1C;PTP1C;Ptpn6;SH PTP 1;SH PTP1;SH-PTP1;SHP 1;SHP 1L;SHP1;SHP1L;tyrosine protein phosphatase non receptor type 6;Tyrosine-protein phosphatase non-receptor type 6 |
Swissprot | |
Calculated MW | 68kDa |
Cellular Localization | Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II. |
Concentration | 0.3 mg/mL |
Buffer | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
Purification Method | Affinity purification |
Research Areas | Cancer; Cell Biology; Developmental Biology; Signal Transduction |
Conjugation | Unconjugated |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Shipping | Biological ice pack at 4 ℃ |
background | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. |
Experiment Operation Video
Protocols
• Western Blot Guide
• Immunohistochemistry Guide for Slide-mounted Paraffin Sections
• Immunofluorescence Guide
• Immunohistochemistry Troubleshooting Tips
• Western Blot Troubleshooting Tips
• Immunofluorescence Troubleshooting Tips
• Comparison of Protein Separation Linear Range
• ImmunoPrecipitation Protocol