SLC12A4 Polyclonal Antibody

Uniprot : Q9UP95
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14350

      Synonyms:Electroneutral potassium chloride cotransporter 1,Electroneutral potassium-chloride cotransporter 1,Erythroid K Cl cotransporter 1,Erythroid K-Cl cotransporter 1,FLJ40489,hKCC 1,hKCC1,KCC 1,KCC1,Potassium transport protein,Potassium/chloride cotransporter 1,S12A4,Slc12a4,Solute carrier family 12 (potassium/chloride transporters) member 4,Solute carrier family 12 member 4

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Electroneutral potassium chloride cotransporter 1,Electroneutral potassium-chloride cotransporter 1,Erythroid K Cl cotransporter 1,Erythroid K-Cl cotransporter 1,FLJ40489,hKCC 1,hKCC1,KCC 1,KCC1,Potassium transport protein,Potassium/chloride cotransporter 1,S12A4,Slc12a4,Solute carrier family 12 (potassium/chloride transporters) member 4,Solute carrier family 12 member 4
      Swissprot Q9UP95
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human SLC12A4
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:50-1:200
      Concentration 0.3 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Membrane.
      Tissue specificity Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
      Background This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl- exit in NaCl absorbing epithelia.

      Images

      Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using SLC12A4 Polyclonal Antibody at dilution 1:30

      Immunohistochemistry of paraffin-embedded Human brain tissue using SLC12A4 Polyclonal Antibody at dilution 1:30

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