SLC4A4 Polyclonal Antibody

Uniprot : Q9Y6R1
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14348

      Synonyms:DKFZp781H1314,Electrogenic sodium bicarbonate cotransporter 1,hhNMC,HNBC 1,HNBC1,kNBC 1,KNBC,kNBC1,Na(+)/HCO3(-) cotransporter,Na+HCO3- cotransporter 4,NBC 1,NBC 2,NBC1,NBC2,Nbc4,NBCE 1,NBCE1,OTTHUMP00000160355,OTTHUMP00000218884,OTTHUMP00000218885,PNBC,S4A4,SLC4A4,SLC4A5,Sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter,kidney,sodium bicarbonate cotransporter,pancreas),Sodium bicarbonate cotransporter,Sodium bicarbonate cotransporter kidney,sodium bicarbonate cotransporter member 4,Sodium bicarbonate cotransporter pancreas,Solute carrier family 4 member 4,Solute carrier family 4 sodium bicarbonate cotransporter member 4,Solute carrier family 4 sodium bicarbonate cotransporter member 5,Solute carrier family 4,sodium bicarbonate cotransporter,member 4,brain type

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms DKFZp781H1314,Electrogenic sodium bicarbonate cotransporter 1,hhNMC,HNBC 1,HNBC1,kNBC 1,KNBC,kNBC1,Na(+)/HCO3(-) cotransporter,Na+HCO3- cotransporter 4,NBC 1,NBC 2,NBC1,NBC2,Nbc4,NBCE 1,NBCE1,OTTHUMP00000160355,OTTHUMP00000218884,OTTHUMP00000218885,PNBC,S4A4,SLC4A4,SLC4A5,Sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter,kidney,sodium bicarbonate cotransporter,pancreas),Sodium bicarbonate cotransporter,Sodium bicarbonate cotransporter kidney,sodium bicarbonate cotransporter member 4,Sodium bicarbonate cotransporter pancreas,Solute carrier family 4 member 4,Solute carrier family 4 sodium bicarbonate cotransporter member 4,Solute carrier family 4 sodium bicarbonate cotransporter member 5,Solute carrier family 4,sodium bicarbonate cotransporter,member 4,brain type
      Swissprot Q9Y6R1
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human SLC4A4
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:50-1:200
      Concentration 0.4 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Basolateral cell membrane.
      Tissue specificity Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate cotransport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states.

      Images

      Immunohistochemistry of paraffin-embedded Human brain tissue using SLC4A4 Polyclonal Antibody at dilution 1:50

      Immunohistochemistry of paraffin-embedded Human colon cancer tissue using SLC4A4 Polyclonal Antibody at dilution 1:50

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