SORT1 Polyclonal Antibody (E-AB-13686)
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For research use only.
| Verified Samples |
Verified Samples in WB: Mouse brain, Human brain, Human prostate, Human fat, Human placenta Verified Samples in IHC: Human liver cancer, Human breast cancer |
| Dilution | WB 1:500-1:2000, IHC 1:35-1:150 |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human SORT1 |
| Abbre | SORT1 |
| Synonyms | 100 kDa NT receptor, Glycoprotein 95, Gp 95, Gp95, LDLCQ6, Neurotensin receptor 3, NT 3, NT3, NTR 3, NTR3, OTTHUMP00000013784, SORT, SORT 1, Sort1, SORT1 (gene name), Sortilin, Sortilin 1, Sortilin抗体 |
| Swissprot | |
| Calculated MW | 92 kDa |
| Cellular Localization | Membrane. Endoplasmic reticulum membrane. Endosome membrane. Golgi apparatus>Golgi stack membrane. Lysosome membrane. Nucleus membrane. Cell membrane. Lysosome membrane. Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin. |
| Concentration | 0.7 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cardiovascular, Metabolism, Neuroscience |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein.The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor.In the TGN, furin mediates the activation of the mature binding form.The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. |
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