UPF1 Polyclonal Antibody
- +1
Price: $ 399
Price: $ 240
Price: $ 143
Price: $ 73
Size:
200μL
120μL
60μL
20μL
Quantity:
- Host: Rabbit
- Reactivity: Human;Mouse
- Applications: WB;IHC
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Product Details
Verified Samples |
Verified Samples in WB:Raji Verified Samples in IHC:Human liver cancer,Human thyroid cancer |
Dilution |
WB 1:200-1:1000, IHC 1:50-1:200 Western Blot Operation Guide |
Clonality | Polyclonal |
Immunogen | Synthetic peptide of human UPF1 |
Abbre | UPF1 |
Synonyms | ATP dependent helicase RENT1;ATP-dependent helicase RENT1;Delta helicase;FLJ43809;FLJ46894;HUPF 1;hUpf1;KIAA0221;Nonsense mRNA reducing factor 1;NORF 1;NORF1;pNORF 1;pNORF1;Regulator of nonsense transcripts 1;RENT 1;RENT1;RENT1;Smg 2;Smg 2 homolog nonsense mediated mRNA decay factor;UP Frameshift 1;Up frameshift mutation 1 homolog (S. cerevisiae);Up frameshift mutation 1 homolog;Up frameshift suppressor 1 homolog;Up-frameshift suppressor 1 homolog;UPF 1;UPF 1 regulator of nonsense transcripts homolog;upf1;UPF1 regulator of nonsense transcripts homolog;UPF1 RNA helicase and ATPase;Yeast Upf1p homolog |
Swissprot | |
Calculated MW | 124kDa |
Cellular Localization | Cytoplasm. Cytoplasm>P-body. Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm. |
Concentration | 0.1 mg/mL |
Buffer | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
Purification Method | Affinity purification |
Research Areas | Cancer; Epigenetics and Nuclear Signaling |
Conjugation | Unconjugated |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Shipping | Biological ice pack at 4 ℃ |
background | This gene encodes a protein that is part of a post-splicing multiprotein complex involved in botHuman, MouseRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. |
Experiment Operation Video
Protocols
• Western Blot Guide
• Immunohistochemistry Guide for Slide-mounted Paraffin Sections
• Immunofluorescence Guide
• Immunohistochemistry Troubleshooting Tips
• Western Blot Troubleshooting Tips
• Immunofluorescence Troubleshooting Tips
• Comparison of Protein Separation Linear Range
• ImmunoPrecipitation Protocol