ABI1 Polyclonal Antibody (E-AB-15453)
For research use only.
| Verified Samples |
Verified Samples in WB: Human brain Verified Samples in IHC: Human cervical cancer, Human gastric cancer |
| Dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human ABI1 |
| Abbre | ABI1 |
| Synonyms | ABI1, Abelson interactor 1, Abi-1, Abi1, Abl binding protein 4, Abl interactor 1, Abl interactor protein 1, Abl-binding protein 4, AblBP4, Eps8 SH3 domain binding protein, Eps8 SH3 domain-binding protein, Eps8 binding protein, Eps8-binding protein, Hssh3bp1, Inter, e3B1 |
| Swissprot | |
| Calculated MW | 55 kDa |
| Cellular Localization | Cytoplasm. Nucleus. Cell projection>lamellipodium. Cell projection>filopodium. Cell projection>growth cone. Cell junction>synapse>synaptosome. Cytoplasm>cytoskeleton. Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cell Biology, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14 |
Other Clones
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Other Formats
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Unconjugated
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