APC Anti-Human CD46 Antibody[TRA-2-10] (AN00324E)

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Cell Markers

Size	Price	Qty
100Tests	$ 220.00	- +
20Tests	$ 93.00	- +
100Tests×2	$ 396.00	- +

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Conjugation: APC

Isotype	Mouse IgG1, κ
Host	Mouse
Reactivity	Human
Applications	FCM
Clonality	Monoclonal
Isotype Control	APC Mouse IgG1, κ Isotype Control[MOPC-21]
Abbre	CD46
Synonyms	Complement membrane cofactor protein, measles virus receptor, MCP
Swissprot	P15529
Cellular Localization	Membrane
Concentration	5 μL/Test
Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Clone No.	TRA-2-10
Conjugation	APC
Conjugation Information	APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter).
Spectrum
Storage	This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Shipping	Ice bag
background	CD46 is a transmembrane protein that is known as a complement membrane cofactor protein, MCP, and measles virus receptor. It is widely expressed on leukocytes, platelets, epithelial cells, and fibroblasts. Multiple isoforms of CD46 have been reported with molecular weights ranging from 45-75 kD. CD46 binds complement components C3b and C4b and has been reported to play a role in T cell regulation. In addition to the complement components, CD46 has been shown to interact with moesin, c-Src, tetraspanin 4, c-Yes, and integrin β1. CD46 is also known to be a cellular receptor for human measles virus and human herpes virus-6 as well as other human pathogens, such as Streptococcus pyogenes. Defects in CD46 have been associated with hemolytic-uremic syndrome.