APC Anti-Mouse CD186 Antibody[Cx6Mab-1] (AN01068E)
| Alternate Names | CXC-R6, CXCR-6 |
| Clone | |
| Background | The Cx6Mab-1 monoclonal antibody reacts with the N-terminal extracellular ligand-binding domain of mouse CXC chemokine receptor 6 (mCXCR6) also known as CD186, BONZO, or STRL33. CXCR6 is expressed on naive CD8+ T cells and a subset of memory CD4+ T cells, natural killer T cells (NKTs), dendritic cells (DCs), pulmonary alveolar macrophages, and innate lymphoid cells (ILCs). The ligand for CXCR6 is C-X-C chemokine CXCL16 that is predominantly expressed in DCs, monocytes, and various other tissue cells, primarily epithelial cells. The CXCR6-CL16 interaction guides immune cell homing (T lymphocyte migration to peripheral tissues) and their activation, expansion, and cytotoxic activity. Retroviruses such as simian immunodeficiency viruses (SIVs), some strains of HIV-2, and macrophage-tropic HIV-1 use CXCR6 as a coreceptor in conjunction with CD4 to enter target cells. In solid tumors, CXCR6 mediates CD8+ T-cell homing to tumor stromal perivascular niches and promotes interactions with CXCL16+ DCs and IL-15 expression for facilitating the growth of T-cells inside the tumor microenvironment. CXCR6 expression is also linked to the activation of Akt/mTOR and ERK/MAPK pathways and other downstream targets responsible for cancer growth and metastasis. CXCR6’s prognostic significance varies among malignancies, but it is regarded as a reliable biomarker to predict the response to anti-PD-1 immunotherapy in various cancers. |
| Abbre | CD186 |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Isotype | Rat IgG1, κ |
| Isotype Control | APC Rat IgG1, κ Isotype Control[HRPN] |
| Applications |
FCM
|
| Cellular Localization |
Membrane
|
| Form | Liquid |
| Concentration |
5 μL/Test
|
| Conjugation | APC |
| Conjugation Information | APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter). |
| Spectrum | |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Storage | This product can be stored at 2-8°C for 24 months. Please protected from prolonged exposure to light and do not freeze. |
| Expiration Date | 24 months |
| Shipping | Ice bag |
| Cat.No. | Product Name | Clone No. |
|---|---|---|
| AN01141E | APC Anti-Mouse CD186 Antibody[SA051D1] | SA051D1 |
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