AQP2 Polyclonal Antibody (E-AB-12274)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human liver cancer, Human tonsil |
| Dilution | IHC 1:100-1:300 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human AQP2 |
| Abbre | AQP2 |
| Synonyms | ADH water channel, AQP 2, AQP CD, AQP-2, AQP-CD, AQP2, AQPCD, Aquaporin 2 collecting duct, Aquaporin CD, Aquaporin-2, Aquaporin-CD, Aquaporin2, Aquaporine 2, Collecting duct water channel protein, MGC34501, Water channel aquaporin 2, Water channel protein for renal |
| Swissprot | |
| Cellular Localization | Apical cell membrane. Basolateral cell membrane. Cytoplasmic vesicle membrane. Golgi apparatus, trans-Golgi network membrane. Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated. |
| Concentration | 0.7 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The basic job of aquaporin 2 is to reabsorb water from the urine while its being removed from the blood by the kidney. Aquaporin 2 is in kidney epithelial cells and usually lies dormant in intracellular vesicle membranes, but when it is needed vasopressin binds to the cell surface vasopressin receptor, activating a signaling pathway that causes the aquaporin 2 containing vesicles to fuse with the plasma membrane so the aquaporin 2 can be used by the cell. |
Other Clones
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Other Formats
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Unconjugated
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