ARC Polyclonal Antibody (E-AB-10826)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human colon cancer, Human brain |
| Dilution | IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human ARC |
| Abbre | ARC |
| Synonyms | ARC, ARC/ARG3.1, Activity-regulated cytoskeleton-associated protein, Activity-regulated gene 3.1 protein homolog, Arc, Arg3.1, activity regulated cytoskeleton associated protein, activity regulated gene 3.1 protein homolog |
| Swissprot | |
| Cellular Localization | Cytoplasm>cytoskeleton. Endosome. Cytoplasmic vesicle>secretory vesicle>acrosome. Cell junction>synapse>postsynaptic cell membrane>postsynaptic density. Cell projection>dendrite. Cell projection>dendritic spine. Cell junction>synapse. Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity). Enriched on the plasma membrane. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Neuroscience |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Arc (for activity-regulated cytoskeleton-associated protein) is a growth factor and immediate early gene that is enriched in brain. Arc mRNA and protein levels are induced by neuronal activity, which is necessary to stimulate neuroplasticity, indicating a potential role for Arc in activity-dependent changes in dendrite function. Arc expression has been detected in neuronal cell bodies and dendrites in the hippocampus, amygdala, hypothalamus, striatum and cortex. Arc has been shown to localize to the cytoskeleton of neuronal cells and appears to colocalize with F-Actin, although it may associate with an Actin-associated protein rather than directly with F-Actin. It has been shown that cocaine-stimulated neuronal activity results in increased Arc mRNA levels in striatum. |
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Unconjugated
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