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For research use only.

Verified Samples Verified Samples in IHC: Human lung cancer, Human thyroid cancer
Dilution IHC 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse,  Rat
Applications IHC
Clonality Polyclonal
Immunogen Recombinant protein of human ASL
Abbre ASL
Synonyms ARLY,  ASAL,  ASL,  Argininosuccinase,  Argininosuccinate lyase,  Arginosuccinase,  EC 4.3.2.1
Swissprot
Cellular Localization Cytosol, Extracellular region or secreted, extracellular exosome, Other locations: cytoplasm.
Concentration 0.2 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer,  Metabolism,  Signal Transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background This gene encodes a member of the lyase 1 family.The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle.Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency.A nontranscribed pseudogene is also located on the long arm of chromosome 22.Alternatively spliced transcript variants encoding different isoforms have been described.
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Unconjugated

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