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For research use only.

Verified Samples Verified Samples in IHC: Human colon cancer, Human esophagus cancer
Dilution IHC 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Human
Applications IHC
Clonality Polyclonal
Immunogen Recombinant protein of human BAD
Abbre BAD
Synonyms AI325008,  BAD,  BBC 2,  BBC2,  BBC6,  BCL X / BCL 2 Binding Protein,  BCL X Binding Protein,  Bcl 2 Antagonist of Cell Death,  Bcl 2 Binding Component 6,  Bcl XL/Bcl 2 Associated Death Promoter,  Bcl-2-binding component 6,  Bcl-2-like protein 8,  Bcl-XL/Bcl-2-associated dea
Swissprot
Cellular Localization Mitochondrion outer membrane. Cytoplasm. Upon phosphorylation, locates to the cytoplasm.
Concentration 0.4 mg/mL
Buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method Affinity purification
Research Areas Cancer,  Cell Biology,  Metabolism
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
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Unconjugated

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